LymphedemaV1, France, Analysis, bibRecord, 000373

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Identifieur interne : 000373 ( France/Analysis ); précédent : 000372; suivant : 000374

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Auteurs : Johanna Manner [Allemagne] ; Bernhard Radlwimmer [Allemagne] ; Peter Hohenberger [Allemagne] ; Katharina Mössinger [Allemagne] ; Stefan Küffer [Allemagne] ; Christian Sauer [Allemagne] ; Djeda Belharazem [Allemagne] ; Andreas Zettl [Suisse] ; Jean-Michel Coindre [France] ; Christian Hallermann [Allemagne] ; Jörg Thomas Hartmann [Allemagne] ; Detlef Katenkamp [Allemagne] ; Kathrin Katenkamp [Allemagne] ; Patrick Schöffski [Belgique] ; Raf Sciot [Belgique] ; Agnieszka Wozniak [Belgique] ; Peter Lichter [Allemagne] ; Alexander Marx [Allemagne] ; Philipp Strbbel [Allemagne]

Source :

The American journal of pathology [ 0002-9440 ] ; 2010.

RBID : Pascal:10-0078175

Descripteurs français

Pascal (Inist)
- Angiosarcome, Gène myc, Haut, Lymphoedème, Amplification génique, Irradiation, Chronique, Anatomopathologie, Sarcome.
Wicri :
- topic : Irradiation.

English descriptors

KwdEn :
- Anatomic pathology, Angiosarcoma, Chronic, Gene amplification, High, Irradiation, Lymphedema, Sarcoma, myc Gene.

Abstract

Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors second-ary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.

Affiliations:

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Le document en format XML

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</author>
<author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institut Bergonié and Laboratory of Pathology, University Victor Ségalen</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Dermatology Fachklinik Hornheide</s1>
<s2>Münster</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Medical Oncology, Medical Center II, Eberhard-Karls-University</s1>
<s2>Tuebingen</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institute of Pathology, University of Jena</s1>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>Institute of Pathology, University of Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institute of Pathology, University of Jena</s1>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>Institute of Pathology, University of Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven</s1>
<s2>Leuven</s2>
<s3>BEL</s3>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven</s1>
<s3>BEL</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<wicri:noRegion>Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven</s1>
<s2>Leuven</s2>
<s3>BEL</s3>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Belgique</country>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>German Cancer Research Center (DKPZ), Division of Molecular Genetics</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelherg</wicri:noRegion>
<wicri:noRegion>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strbbel, Philipp" sort="Strbbel, Philipp" uniqKey="Strbbel P" first="Philipp" last="Strbbel">Philipp Strbbel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Heidelherg</wicri:noRegion>
<wicri:noRegion>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The American journal of pathology</title>
<title level="j" type="abbreviated">Am. j. pathol.</title>
<idno type="ISSN">0002-9440</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The American journal of pathology</title>
<title level="j" type="abbreviated">Am. j. pathol.</title>
<idno type="ISSN">0002-9440</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
<term>Angiosarcoma</term>
<term>Chronic</term>
<term>Gene amplification</term>
<term>High</term>
<term>Irradiation</term>
<term>Lymphedema</term>
<term>Sarcoma</term>
<term>myc Gene</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Angiosarcome</term>
<term>Gène myc</term>
<term>Haut</term>
<term>Lymphoedème</term>
<term>Amplification génique</term>
<term>Irradiation</term>
<term>Chronique</term>
<term>Anatomopathologie</term>
<term>Sarcome</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Irradiation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors second-ary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>France</li>
<li>Suisse</li>
</country>
<region><li>Aquitaine</li>
<li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>District de Münster</li>
<li>District de Tübingen</li>
<li>Nouvelle-Aquitaine</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bordeaux</li>
<li>Heidelberg</li>
<li>Münster</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name>
</noRegion>
<name sortKey="Belharazem, Djeda" sort="Belharazem, Djeda" uniqKey="Belharazem D" first="Djeda" last="Belharazem">Djeda Belharazem</name>
<name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
<name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name>
<name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name>
<name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name>
<name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name>
<name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name>
<name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name>
<name sortKey="Radlwimmer, Bernhard" sort="Radlwimmer, Bernhard" uniqKey="Radlwimmer B" first="Bernhard" last="Radlwimmer">Bernhard Radlwimmer</name>
<name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name>
<name sortKey="Strbbel, Philipp" sort="Strbbel, Philipp" uniqKey="Strbbel P" first="Philipp" last="Strbbel">Philipp Strbbel</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Zettl, Andreas" sort="Zettl, Andreas" uniqKey="Zettl A" first="Andreas" last="Zettl">Andreas Zettl</name>
</noRegion>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name>
</region>
</country>
<country name="Belgique"><noRegion><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
</noRegion>
<name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
<name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name>
</country>
</tree>
</affiliations>
</record>

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MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

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